Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs
نویسندگان
چکیده
منابع مشابه
Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs
BACKGROUND Polymyxin is a cationic polypeptide antibiotic that can disrupt bacterial cell membrane by interacting with its lipopolysaccharide molecules and is used as a last resort drug against lethal infections by the carbapenem-resistant superbugs (like NDM-1). However, global discovery of the MCR-1 colistin resistance dramatically challenges the newly renewed interest in colistin for clinica...
متن کاملDiversified mcr-1-Harbouring Plasmid Reservoirs Confer Resistance to Colistin in Human Gut Microbiota.
UNLABELLED Colistin is an ultimate line of refuge against multidrug-resistant Gram-negative pathogens. Very recently, the emergence of plasmid-mediatedmcr-1colistin resistance has become a great challenge to global public health, raising the possibility that dissemination of themcr-1gene is underestimated and diversified. Here, we report three cases of plasmid-carried MCR-1 colistin resistance ...
متن کاملMultiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes
Background and aimPlasmid-mediated colistin resistance mechanisms have been identified worldwide in the past years. A multiplex polymerase chain reaction (PCR) protocol for detection of all currently known transferable colistin resistance genes (mcr-1 to mcr-5, and variants) in Enterobacteriaceae was developed for surveillance or research purposes. Methods: We designed four new primer pairs to ...
متن کاملComplex dissemination of the diversified mcr-1-harbouring plasmids in Escherichia coli of different sequence types
The emergence of the mobilized colistin resistance gene, representing a novel mechanism for bacterial drug resistance, challenges the last resort against the severe infections by Gram-negative bacteria with multi-drug resistances. Very recently, we showed the diversity in the mcr-1-carrying plasmid reservoirs from the gut microbiota. Here, we reported that a similar but more complex scenario is...
متن کاملPlasmid Curing Activity of Five Plant Extracts on Multiple Resistant Plasmid Bearing Klebsiella Pnumoniae Strains
ABSTRACT The curing of five medicinal plant extracts (Satureia hortensis, Glycyrrhiza glabra, Teucrium Pollium, Myrtus Communis, Eukalypetus globolus) on plasmid bearing strains of klebsilla pnenmoniae resistance to multiple antibiotics were investigated. Alcoholic and maceration extraction were carried out from leaves, fruits or roots of the above plants. Mimimum inhibitory concentrations (MI...
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ژورنال
عنوان ژورنال: Microbiome
سال: 2017
ISSN: 2049-2618
DOI: 10.1186/s40168-017-0288-0